There are a few ways to convert nitriles to esters. Let’s start with the Pinner reaction, which, although not commonly highlighted in textbooks, is a direct and efficient method for this transformation. Pinner Reaction for Converting Nitriles to Esters … Read more
Addition of Organolithiums to Carboxylic Acids One of the most common ways of converting carboxylic acids to ketones is their reaction with organolithiums. The first step is the deprotonation of the acid since organolithiums are also very strong … Read more
In this conversion series, we mention how nitriles can be converted to ketones and aldehydes. Nitriles are converted to ketones by both Grignard and organolithium reagents: The new C-C bonds are formed by nucleophilic addition of the organometallic … Read more
Esters can be converted to alcohols by two types of reduction reactions. One is the reduction by a strong reducing agent such as LiAlH4 to a primary alcohol, and the second is the conversion to a tertiary alcohol by reacting … Read more
