Protecting Groups Archives - Chemistry Steps

Acetals as Protecting Groups for Aldehydes and Ketones

reduce ester in presence of aldehyde with lialh4 steps

Acetals are the protecting groups for aldehydes and ketones. They can be used, for example, when a selective reduction of an ester is needed in the presence of an aldehyde or a ketone: Remember, aldehydes are more reactive … Read more

Protecting Groups For Alcohols

by Dr. S. Gevorg

Protection and deprotection of alcohols by a common silyl ether - trimethylsilyl (TMS)

Why do you think the following Grignard reaction is impossible to carry out without having a protecting group on the alcohol? What is even a protecting group? These are the questions we are going to address in today’s article. … Read more