In the previous post, we talked about the Cahn-Ingold-Prelog rules for assigning the R and S configuration. In the following practice problems, we will assign the R and S configuration for bond-line representations and use it to determine the relationship between the two compounds (identical, enantiomers or diastereomers), and also assign the R and S configuration on Fischer projections:
The R and S Configuration Practice Problems
Practice
1.
Identify all the chiral centers in each molecule and determine the absolute configuration as R or S:
Answer
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Solution
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2.
Identify all the chiral centers in each Fischer projection and determine the absolute configuration as R or S:
Answer
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Solution
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3.
For each of the following pairs of compounds, determine the relationship between the two compounds: Are they enantiomers or the same compound drawn differently? If you hesitate, determine the absolute configuration of chiral centers (if any: R or S).
Answer
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Solution
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Answer
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Answer
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Answer
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By joining Chemistry Steps, you will gain instant access to the answers and solutions for all the Practice Problems, including over 40 hours of problem-solving videos, Multiple-Choice Quizzes, Puzzles, Reaction Maps, and the powerful set of Organic Chemistry 1 and 2 Summary Study Guides.
Answer
This content is for registered users only.
By joining Chemistry Steps, you will gain instant access to the answers and solutions for all the Practice Problems, including over 40 hours of problem-solving videos, Multiple-Choice Quizzes, Puzzles, Reaction Maps, and the powerful set of Organic Chemistry 1 and 2 Summary Study Guides.
5.
Practicing R and S is never too much. This 1.5-hour video is a collection of examples taken from the multiple choice quizzes determining the R and S configuration in the context of naming compounds, determining the relationship between compounds, and chemical reactions.
This content is for registered users only.
By joining Chemistry Steps, you will gain instant access to the answers and solutions for all the Practice Problems, including over 40 hours of problem-solving videos, Multiple-Choice Quizzes, Puzzles, Reaction Maps, and the powerful set of Organic Chemistry 1 and 2 Summary Study Guides.
6.
Check Also
- How to Determine the R and S Configuration
- What is Nonsuperimposable in Organic Chemistry
- Chirality and Enantiomers
- Diastereomers-Introduction and Practice Problems
- Enantiomers vs Diastereomers
- Cis and Trans Stereoisomerism in Alkenes
- E and Z Alkene Configuration with Practice Problems
- Enantiomers vs Diastereomers
- Enantiomers, Diastereomers, the Same or Constitutional Isomers with Practice Problems
- Configurational Isomers
- Optical Activity
- Specific Rotation
- Racemic Mixtures
- Enantiomeric Excess (ee): Percentage of Enantiomers from Specific Rotation with Practice Problems
- Symmetry and Chirality. Meso Compounds
- Fischer Projections with Practice Problems
- R and S Configuration in the Fischer Projection
- R and S configuration on Newman projections
- R and S Configuration of Allenes
- Converting Bond-Line, Newman Projection, and Fischer Projections
- Resolution of Enantiomers: Separate Enantiomers by Converting to Diastereomers
- Stereochemistry Practice Problems
- Stereochemistry Practice Quiz
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