To determine the R and S configuration of a chiral carbon in Newman projections, we need to look through the bond such that the lowest priority group is pointing back. But first, one question – why would anyone need to … Read more
To determine the R and S configuration of the chiral carbon atoms in a Fischer projection, we first need to recall the concept of the Fischer projection. And that is, the horizontal groups are pointing towards the viewer (wedge), and … Read more
In this post, we will learn how to convert between Fischer, Bond-line, and Newman projections in different orders. This is an essential skill as it helps to visualize the molecule in space, and that is what a significant part of … Read more
Today, we will talk about another type of stereoisomers, which are called diastereomers. This may be overwhelming since at this point you are probably trying to keep track of constitutional isomers, stereoisomers, enantiomers, and not being tricked when the same … Read more
What is the R and S Configuration, and why do we need it? If we name these two alkyl halides based on the IUPAC nomenclature rules, we get the name as 2-chlorobutane for both: … Read more
You have learned and seen in general and organic experimental sections that compounds can be separated using techniques such as filtration, distillation, crystallization, etc. On the basis of all these techniques is the fact that the compounds have different physical … Read more
What are the Fischer Projections? Fischer projections are just another way of drawing compounds containing chiral centers. They were initially proposed by Emil Fischer for making it easier to draw the structures of compounds containing multiple chiral centers, with the … Read more
In my experience of teaching, I have noticed that conveying the message about meso compounds is a lot easier when Fischer projections are used. So, we will talk about it by drawing the Fischer projections of three isomers of 2,3-dichlorobutane: … Read more
Check Also in Stereochemistry: Enantiomeric excess (ee) Stereoisomerism Chirality and Enantiomers The R and S system to label chiral centers Diastereomers Optical Activity Calculating Enantiomeric Excess from Optical Activity Symmetry and Chiralty. Meso Compunds Fischer projection
When we learned about enantiomers, we mentioned that they have identical physical properties – melting point, boiling point, and solubility. So, one question you may wonder about is how we distinguish enantiomers if they all seem to be identical. Yes, … Read more
