Crossed Aldol Condensation Practice Problems

In the previous post, we learned that the crossed aldol condensation is the aldol reaction between two different carbonyl compounds. This is also known as a mixed aldol reaction.

Crossed aldol reactions have the advantage of controlling which carbonyl compound serves as the nucleophile and thus avoiding the undesired mixture of products. Go over the article and use this principle to solve the following practice problems on crossed aldol condensation.

 

Practice

1.

Draw the product formed in each of the following directed aldol reactions.

a)
Answer

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b)
Answer

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c)
Answer

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2.

What starting material is needed to prepare each compound by an aldol reaction? Specify the compound that is deprotonated and then acts as the nucleophile and show the steps in the correct order.

a)
Answer

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b)
Answer

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c)
Answer

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d)
Answer

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e)
Answer

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f)
Answer

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