Wohl Degradation

The Wohl degradation shortens an aldose chain by cleaving the C1-C2 bond

The Wohl degradation cleaves the C1–C2 bond of an aldose chain, shortening it by one carbon. Like in the Kiliani–Fischer synthesis, the transformation relies on first converting the aldehyde group to a cyanohydrin.     Notice, however, the key difference: the (red) … Read more