If a compound has two carbonyl groups (dicarbonyl compound), it undergoes an intramolecular aldol reaction if a five- or six-membered ring can be formed: What happens is one of the carbonyls is deprotonated at the ɑ position, thus … Read more
In the previous post, we talked about the Claisen condensation reaction and went over the mechanism as well as some details regarding the importance of at least two α hydrogens. Check those if you need to, before working on the … Read more
In the previous post, we learned that the crossed aldol condensation is the aldol reaction between two different carbonyl compounds. This is also known as a mixed aldol reaction. Crossed aldol reactions have the advantage of controlling which carbonyl compound serves … Read more
Acyl chlorides can be prepared by reacting carboxylic acids with thionyl chloride (SOCl2), phosphorous trichloride (PCl3) or phosphorous pentachloride (PCl5): In the bases of this transformation is the conversion of the OH group into a good leaving. For … Read more
