Acyl chlorides, being the most reactive among carboxylic acid derivatives, undergo a wide variety of nucleophilic acyl substitution reactions. A quick reminder, in a nucleophilic acyl substitution, the leaving group is replaced by a nucleophile by the addition-elimination mechanism: … Read more
We have already talked about the ortho, para, and meta directions in electrophilic aromatic substitution and their combined effect for disubstituted benzene. This should allow us to synthesize different aromatic compounds starting from benzene. For example, how can we synthesize … Read more
In the previous post, we learned about the Friedel–Crafts alkylation and discussed its mechanism and limitations. In Friedel–Crafts acylation, aromatic compounds are reacted with an acyl halide to prepare an aryl ketone: The electrophile in this reaction is … Read more
