The main difference of the Grignard reaction compared to everything else you learn in the reactions of alcohols is that it is another way of making a new C-C bond and extending the carbon chain of the molecule. The most … Read more
In this post, we will talk about the Grignard reaction – a fundamental reaction in organic chemistry discovered by Victor Grignard in 1912, which gave him the Nobel Prize. The most common and important Grignard reaction is the one with … Read more
Importance of radical Halogenation The source of the large majority of organic materials used for a countless number of applications, which can be plastics, drugs, paints, clothes, electronics and many more is the crude oil. We need to … Read more
The first practice problem is a summary of alkyne reactions, followed by comprehensive synthesis practice problems; all the major classes of alkyne and alkene reactions are covered!These include the preparation of dialkyl halides and their use in the preparation of … Read more
Alkylation of Terminal Alkynes Many reactions of alkynes are similar to those of alkenes, as they are both π-bond systems that are capable of doing electrophilic addition reactions. One important difference is the acidity of the alkyne proton. The pKa … Read more
In the previous post, we talked about a simple strategy you can use for changing the position of a double bond. A similar tool-set, commonly used in organic synthesis, is the change of the position for a leaving group: … Read more
Changing the position of a double bond is a very important tool in organic synthesis. For example, let’s try to figure out what happens in this transformation: The double bond has suddenly moved to produce a new regioisomer … Read more
This is a comprehensive problem that covers the following topics and will serve as a review of all of them: Substitution and elimination reactions. Particularly, substitution and elimination reactions of alcohols, the regio– and stereochemistry of E2 reactions and E2 reaction … Read more
