In this post, we will talk about the ortho-, meta, and para directors in electrophilic aromatic substitution (EAS). As a reminder, the ortho-, meta, and para are the relative positions of the two groups in a disubstituted aromatic ring: … Read more
We have seen, in the Friedel-Crafts alkylation reaction, that rearrangements do not allow for the preparation of primary alkyl benzenes: To overcome this limitation, you can first prepare the corresponding aryl ketone by the Friedel-Crafts acylation and then … Read more
In the previous post, we learned about the Friedel–Crafts alkylation and discussed its mechanism and limitations. In Friedel–Crafts acylation, aromatic compounds are reacted with an acyl halide to prepare an aryl ketone: The electrophile in this reaction is … Read more
In the previous post, we learned about the electrophilic aromatic substitution reactions and went over the mechanisms of halogenation, nitration, and sulfonation of the benzene ring. Following an identical mechanism, two reactions, discovered by Charles Friedel and James Crafts in … Read more
Benzene has 3 π bonds and, as expected, shows some similarities to alkenes in being reactive towards electrophilic species. However, there are two key differences between their reactions with electrophiles. First, benzene is very stable and thus less reactive. Second, unlike … Read more
