Acyl chlorides can be prepared by reacting carboxylic acids with thionyl chloride (SOCl2), phosphorous trichloride (PCl3) or phosphorous pentachloride (PCl5): In the bases of this transformation is the conversion of the OH group into a good leaving. For … Read more
In this chapter on aldehydes and ketones, we are going to see a new type of reaction – the nucleophilic addition to the carbonyl (C=O) bond: The nucleophilic addition to the carbonyl group occurs as a result of … Read more
In the previous post, we learned about the Friedel–Crafts alkylation and discussed its mechanism and limitations. In Friedel–Crafts acylation, aromatic compounds are reacted with an acyl halide to prepare an aryl ketone: The electrophile in this reaction is … Read more
